Genetic Manipulation of Streptococcus pyogenes (The Group A Streptococcus, GAS)

Streptococcus pyogenes ( Group A Streptococcus )

Group A streptococcus (GAS) is synonymous with Streptococcus pyogenes, the only species within this group of β-hemolytic streptococci. GAS is one of the leading pathogenic bacteria that infects children and adolescents, and is associated with a wide spectrum of infections and disease states. Worldwide, there are estimated to be >600 million cases of GAS pharyngitis (“strep throat”) and >100 mil...

Detection of Streptococcus pyogenes by use of Illumigene group A Streptococcus assay.

The performance of the Illumigene group A Streptococcus assay was evaluated by comparing it to culture using 437 consecutive throat swabs. The Illumigene assay was also directly compared to PCR with 161 samples. This Illumigene assay is rapid and easy to perform. The assay also has high sensitivity (100%) compared to culture or PCR and high specificity (99.2%) compared to PCR. A total of 8.8% o...

Studies on Streptococcus Pyogenes

Electron microscopic observations of Streptococcus pyogenes (strain S43, type 6) treated with trypsin and cetyltrimethylammonium bromide (Cetab) are presented. The concentration of trypsin necessary to remove the M protein antigen was shown to bring about a partial digestion of the cells. The cell protoplasm and protoplasmic membrane were affected. No microscopic changes appeared in the cell wa...

Upper limb compartment syndrome secondary to streptococcus pyogenes (Group A streptococcus) infection

Compartment syndrome caused by Streptococcus pyogenes (Group A streptococcus) has rarely been described. We report a case of a healthy 44-year-old male who presented with compartment syndrome of the right forearm and subsequent acute respiratory distress syndrome. The patient received antibiotics and urgent surgical decompression, followed by delayed wound closure without the need for skin graf...

Streptococcus pyogenes adcA